Drug

Afuresertib

As of the edition of 20 October 2026, Afuresertib is a small molecule: in active development; acts on AKT1, AKT2 and AKT3.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Active, 2026
Kind
Small molecule
Registered trials
17, 4 stopped early
Disease areas
Cancer; Blood and lymph; Immune system; Heart and blood vessels; Pregnancy and women's health; Urinary and reproductive

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

3 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

3 company-target rows are on route A because of Afuresertib.

Targets

GeneProteinUniProt
AKT1RAC-alpha serine/threonine-protein kinaseP31749
AKT2RAC-beta serine/threonine-protein kinaseP31751
AKT3RAC-gamma serine/threonine-protein kinaseQ9Y243

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 18503
Phase 28701
Phase 31010
All trials17

Who ran its trials

CompanyRoleYears
GSKLead sponsor of trials2011 to now
NovartisLead sponsor of trials2011 to now
AccentureLead sponsor of trials2012 to now
LaeknaLead sponsor of trials2019 to now