Drug

Cinaciguat

As of the edition of 20 October 2026, Cinaciguat is a small molecule: stopped in 2011; acts on GUCY1A1, GUCY1A2 and GUCY1B1 and 1 more.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2011
Kind
Small molecule
Registered trials
4, 4 stopped early
Disease areas
Heart and blood vessels

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

1 company-target row on route B because of this drug.

Companies on route B for this drug

In the product

1 company-target row is on route B because of Cinaciguat.

Targets

GeneProteinUniProt
GUCY1B2Putative guanylate cyclase soluble subunit beta-2O75343
GUCY1A2Guanylate cyclase soluble subunit alpha-2P33402
GUCY1A1Guanylate cyclase soluble subunit alpha-1Q02108
GUCY1B1Guanylate cyclase soluble subunit beta-1Q02153

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 24004
All trials4

Who ran its trials

CompanyRoleYears
BayerLead sponsor of trials2007 to now