Drug

Runcaciguat

As of the edition of 20 October 2026, Runcaciguat is a small molecule: stopped in 2021; acts on GUCY1A1, GUCY1A2 and GUCY1B1 and 1 more.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2021
Kind
Small molecule
Registered trials
3, 1 stopped early
Disease areas
Pregnancy and women's health; Urinary and reproductive; Eye; Heart and blood vessels; Hormones

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

1 company-target row on route B because of this drug.

Companies on route B for this drug

In the product

1 company-target row is on route B because of Runcaciguat.

Targets

GeneProteinUniProt
GUCY1B2Putative guanylate cyclase soluble subunit beta-2O75343
GUCY1A2Guanylate cyclase soluble subunit alpha-2P33402
GUCY1A1Guanylate cyclase soluble subunit alpha-1Q02108
GUCY1B1Guanylate cyclase soluble subunit beta-1Q02153

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 11001
Phase 22200
All trials3

Who ran its trials

CompanyRoleYears
BayerLead sponsor of trials2020 to now