Probatebeta
Target

GUCY1B1

Guanylate cyclase soluble subunit beta-1

As of the edition of 20 October 2026, GUCY1B1 (guanylate cyclase soluble subunit beta-1, UniProt Q02153) has 15 drugs tested at it and 32 companies on the list, 1 on route A and 7 on route B.

Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.

The protein

UniProt
Q02153
How well studied
Drug target: an approved drug acts on it
Where it sits in the cell
Inside the cell
Solved structures
14
Disease areas
Heart and blood vessels; Lungs and airways; Infections; Urinary and reproductive; Pregnancy and women's health; Nervous system; Cancer; Inherited and neonatal
Registered trials of its drugs
508

Drugs at this target

StatusCount
Marketed9
Active2
Went quiet2
Stopped2
Total15
DrugStatusFurthest phaseUS protection
Nitric oxideMarketedPhase 4Ends 2029
NitroglycerinMarketedPhase 4none listed
Methylene blue cationMarketedPhase 4Ends 2027
RiociguatMarketedPhase 4Ends 2034
NitroprussideMarketedPhase 4none listed
VericiguatMarketedPhase 4Ends 2032
Isosorbide mononitrateMarketedPhase 4none listed
Isosorbide dinitrateMarketedPhase 4none listed
PraliciguatActivePhase 2none listed
OlinciguatWent quietPhase 2none listed
AtaciguatActivePhase 3none listed
CinaciguatStoppedPhase 2none listed

12 of 15 drugs, the most tested first.

Companies at this target

Where the company standsCompanies
Route A1
Route B7
Engaged16
Undetermined8
Total on the list32
Three companies on route A or B, with the route only
CompanyRoute
Merck & Co.Route B
RocheRoute B
Dr. Reddy'sRoute B

The other 29 companies at GUCY1B1

In the product

32 companies in all; 29 are not named here, and no score is.

See the 32 companies at GUCY1B1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.

More drugs at GUCY1B1

Other targets in heart and blood vessels

Companies holding approvals at GUCY1B1