Drug

DE-104

As of the edition of 20 October 2026, DE-104 is a drug: went quiet; acts on ROCK1 and ROCK2.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet
Kind
Unknown
Registered trials
1, 0 stopped early
Disease areas
Eye

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

2 company-target rows on route B because of this drug.

Companies on route B for this drug

In the product

2 company-target rows are on route B because of DE-104.

Targets

GeneProteinUniProt
ROCK2Rho-associated protein kinase 2O75116
ROCK1Rho-associated protein kinase 1Q13464

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 21100
All trials1

Who ran its trials

CompanyRoleYears
Santen PharmaceuticalLead sponsor of trials