Drug

Navitoclax

As of the edition of 20 October 2026, Navitoclax is a small molecule: in active development; acts on BCL2 and BCL2L1.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Active, 2027
Kind
Small molecule
Registered trials
44, 8 stopped early
Disease areas
Cancer; Blood and lymph; Immune system; Urinary and reproductive; Hormones; Lungs and airways

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

1 company-target row on route B and 4 company-target rows on route A because of this drug.

Companies on route B for this drug

In the product

1 company-target row is on route B because of Navitoclax.

Companies on route A for this drug

In the product

4 company-target rows are on route A because of Navitoclax.

Targets

GeneProteinUniProt
BCL2Apoptosis regulator Bcl-2P10415
BCL2L1Bcl-2-like protein 1Q07817

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase not stated2000
Phase 1221552
Phase 218746
Phase 32110
All trials44

Who ran its trials

CompanyRoleYears
AbbVieLead sponsor of trials2006 to now
AbbottLead sponsor of trials2008 to now
RocheLead sponsor of trials2010 to now