Drug

Onalespib

As of the edition of 20 October 2026, Onalespib is a small molecule: stopped in 2022; acts on HSP90AA1 and HSP90AB1.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2022
Kind
Small molecule
Registered trials
13, 4 stopped early
Disease areas
Cancer; Skin and connective tissue; Lungs and airways; Urinary and reproductive; Blood and lymph; Digestive system

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Targets

GeneProteinUniProt
HSP90AA1Heat shock protein HSP 90-alphaP07900
HSP90AB1Heat shock protein HSP 90-betaP08238

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 18503
Phase 25401
All trials13

Who ran its trials

CompanyRoleYears
OtsukaLead sponsor of trials2008 to now