Drug

SB-649868

As of the edition of 20 October 2026, SB-649868 is a small molecule: went quiet in 2010; acts on HCRTR1 and HCRTR2.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2010
Kind
Small molecule
Registered trials
6, 1 stopped early
Disease areas
Mental health; Nervous system; Cancer; Hormones; Inherited and neonatal

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

2 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

2 company-target rows are on route A because of SB-649868.

Targets

GeneProteinUniProt
HCRTR1Orexin/Hypocretin receptor type 1O43613
HCRTR2Orexin receptor type 2O43614

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 15401
Phase 21100
All trials6

Who ran its trials

CompanyRoleYears
GSKLead sponsor of trials2006 to now