ACACA
Acetyl-CoA carboxylase 1
As of the edition of 20 October 2026, ACACA (acetyl-CoA carboxylase 1, UniProt Q13085) has 5 drugs tested at it and 4 companies on the list, 1 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q13085
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 10
- Disease areas
- Hormones; Nutrition and metabolism; Digestive system; Skin and connective tissue; Mental health; Nervous system
- Registered trials of its drugs
- 35
Drugs at this target
| Status | Count |
|---|---|
| Active | 2 |
| Went quiet | 1 |
| Stopped | 1 |
| Status not established | 1 |
| Total | 5 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| PF-05175157 | Stopped | Phase 2 | none listed |
| Clesacostat | Active | Phase 2 | none listed |
| Firsocostat | Active | Phase 2 | none listed |
| Olumacostat glasaretil | Went quiet | Phase 3 | none listed |
| CMS-121 | Status not established | Phase 1 | none listed |
5 of 5 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 1 |
| Engaged | 2 |
| Undetermined | 1 |
| Total on the list | 4 |
| Company | Route |
|---|---|
| Dermira | Route A |
The other 3 companies at ACACA
In the product4 companies in all; 3 are not named here, and no score is.
See the 4 companies at ACACA, ranked, with the facts behind eachRequest access. Nothing is shown until you do.