ACACB
Acetyl-CoA carboxylase 2
As of the edition of 20 October 2026, ACACB (acetyl-CoA carboxylase 2, UniProt O00763) has 4 drugs tested at it and 3 companies on the list, 1 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O00763
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 11
- Disease areas
- Hormones; Nutrition and metabolism; Digestive system; Skin and connective tissue
- Registered trials of its drugs
- 34
Drugs at this target
| Status | Count |
|---|---|
| Active | 2 |
| Went quiet | 1 |
| Stopped | 1 |
| Total | 4 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| PF-05175157 | Stopped | Phase 2 | none listed |
| Clesacostat | Active | Phase 2 | none listed |
| Firsocostat | Active | Phase 2 | none listed |
| Olumacostat glasaretil | Went quiet | Phase 3 | none listed |
4 of 4 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 1 |
| Engaged | 2 |
| Total on the list | 3 |
| Company | Route |
|---|---|
| Dermira | Route A |
The other 2 companies at ACACB
In the product3 companies in all; 2 are not named here, and no score is.
See the 3 companies at ACACB, ranked, with the facts behind eachRequest access. Nothing is shown until you do.