MMP2
72 kDa type IV collagenase
As of the edition of 20 October 2026, MMP2 (72 kDa type IV collagenase, UniProt P08253) has 4 drugs tested at it and 4 companies on the list, 3 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P08253
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 14
- Disease areas
- Cancer; Infections; Digestive system; Urinary and reproductive; Lungs and airways; Skin and connective tissue; Blood and lymph; Chemically induced
- Registered trials of its drugs
- 14
Drugs at this target
| Status | Count |
|---|---|
| Active | 1 |
| Went quiet | 2 |
| Stopped | 1 |
| Total | 4 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Rebimastat | Stopped | Phase 3 | none listed |
| CTS-1027 | Went quiet | Phase 2 | none listed |
| Marimastat | Active | Phase 3 | none listed |
| XL784 | Went quiet | Phase 2 | none listed |
4 of 4 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 3 |
| Engaged | 1 |
| Total on the list | 4 |
| Company | Route |
|---|---|
| Bristol Myers Squibb | Route A |
| Symphony Evolution | Route A |
| Conatus Pharmaceuticals | Route A |
The other 1 company at MMP2
In the product4 companies in all; 1 is not named here, and no score is.
See the 4 companies at MMP2, ranked, with the facts behind eachRequest access. Nothing is shown until you do.