US protection ending in 2028: Injuries
As of the edition of 20 October 2026, 11 drugs have US protection that ends in 2028 in injuries; 8 of them have at least one company on route B because of it.
Sources: FDA Orange Book and Purple Book, other approval registers.
11 drugs
| Drug | US protection | Status | Holder | Target | Route B rows |
|---|---|---|---|---|---|
| Apixaban | Ends 2028 (exclusivity) | Marketed | Bristol Myers Squibb | F10 | 2 |
| Buprenorphine | Ends 2028 (exclusivity) | Marketed | Indivior | OPRK1, OPRM1 | 9 |
| Empagliflozin | Ends 2028 (patent) | Marketed | Boehringer Ingelheim | SLC5A2 | 1 |
| Esketamine | Ends 2028 (exclusivity) | Marketed | Johnson & Johnson | GRIN1, GRIN2A, GRIN2B | 5 |
| Ferric oxyhydroxide | Ends 2028 (exclusivity) | Marketed | Vifor Fresenius Medical Care Renal Pharma | 0 | |
| Ferumoxytol | Ends 2028 (exclusivity) | Marketed | Azurity Pharmaceuticals | 0 | |
| Olaparib | Ends 2028 (patent) | Marketed | AstraZeneca | PARP1, PARP2, PARP3 | 3 |
| Oxybate | Ends 2028 (exclusivity) | Marketed | GABBR1, GABBR2 | 2 | |
| Rituximab | Ends 2028 (orphan exclusivity) | Marketed | Roche | MS4A1 | 1 |
| Tacrolimus anhydrous | Ends 2028 (exclusivity) | Marketed | Astellas | FKBP1A | 3 |
| Tocilizumab | Ends 2028 (orphan exclusivity) | Marketed | Roche | IL6R | 0 |
Listed by name. A route B row is one company at one target; for a drug with one target that is the number of companies. US protection is the US only, and it is not the date generics or biosimilars can enter.
Which companies are on route B in 2028 in injuries
In the product8 of these 11 drugs have at least one company on route B. Which companies, and their scores, are in the product.
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