Drug

Adenosine

As of the edition of 20 October 2026, Adenosine is a small molecule: marketed, first approved in 1961 (ES); acts on ADORA1, ADORA2A and ADORA2B and 1 more.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Marketed; latest approval 1993
Kind
Small molecule
Brand name
Adenocard
First approved
1 May 1961 (ES)
Approvals on record
6 in 4 regions
Holder of the most recent approval
Astellas; 4 holders in all
Registered trials
54, 9 stopped early
Disease areas
Heart and blood vessels; Immune system; Lungs and airways; Nutrition and metabolism; Cancer; Hormones

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

4 company-target rows on route B because of this drug.

Companies on route B for this drug

In the product

4 company-target rows are on route B because of Adenosine.

Targets

GeneProteinUniProt
ADORA3Adenosine receptor A3P0DMS8
ADORA2AAdenosine receptor A2aP29274
ADORA2BAdenosine receptor A2bP29275
ADORA1Adenosine receptor A1P30542

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase not stated191121
Phase 19621
Phase 211503
Phase 312714
Phase 43210
All trials54

Who has held its approvals

CompanyRoleYears
AstellasApplicant1989 to now
SanofiApplicant and Lead sponsor of trials1992 to now