Probatebeta
Target

ADORA2A

Adenosine receptor A2a

As of the edition of 20 October 2026, ADORA2A (adenosine receptor A2a, UniProt P29274) has 27 drugs tested at it and 34 companies on the list, 12 on route A and 12 on route B.

Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.

The protein

UniProt
P29274
How well studied
Drug target: an approved drug acts on it
Where it sits in the cell
At a membrane
Solved structures
189
Disease areas
Nervous system; Heart and blood vessels; Lungs and airways; Cancer; Urinary and reproductive; Digestive system; Pregnancy and women's health; Immune system
Registered trials of its drugs
729

Drugs at this target

StatusCount
Marketed8
Active2
Went quiet4
Stopped10
Status not established3
Total27
DrugStatusFurthest phaseUS protection
CaffeineMarketedPhase 4none listed
PentoxifyllineMarketedPhase 4none listed
Theophylline anhydrousMarketedPhase 4none listed
AdenosineMarketedPhase 4none listed
Regadenoson anhydrousMarketedPhase 4Ends 2027
IstradefyllineMarketedPhase 4none listed
DefibrotideMarketedPhase 4none listed
EtrumadenantActivePhase 2none listed
PreladenantStoppedPhase 3none listed
CiforadenantStoppedPhase 2none listed
SipagladenantWent quietPhase 2none listed
TozadenantStoppedPhase 3none listed

12 of 27 drugs, the most tested first.

Companies at this target

Where the company standsCompanies
Route A12
Route B12
Engaged6
Undetermined4
Total on the list34
Three companies on route A or B, with the route only
CompanyRoute
PfizerRoute B
Merck & Co.Route A
NovartisRoute A

The other 31 companies at ADORA2A

In the product

34 companies in all; 31 are not named here, and no score is.

See the 34 companies at ADORA2A, ranked, with the facts behind eachRequest access. Nothing is shown until you do.

More drugs at ADORA2A

Other targets in nervous system

Companies holding approvals at ADORA2A