Drug

ENMD-2076

As of the edition of 20 October 2026, ENMD-2076 is a small molecule: went quiet in 2018; acts on AURKA, CSF1R and FGFR3 and 2 more.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2018
Kind
Small molecule
Registered trials
8, 0 stopped early
Disease areas
Cancer; Blood and lymph; Digestive system; Heart and blood vessels; Hormones; Immune system

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

5 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

5 company-target rows are on route A because of ENMD-2076.

Targets

GeneProteinUniProt
AURKAAurora kinase AO14965
CSF1RMacrophage colony-stimulating factor 1 receptorP07333
FGFR3Fibroblast growth factor receptor 3P22607
KDRVascular endothelial growth factor receptor 2P35968
FLT3Receptor-type tyrosine-protein kinase FLT3P36888

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 13300
Phase 25500
All trials8

Who ran its trials

CompanyRoleYears
CASI pharmaceuticalsLead sponsor of trials2008 to now