AURKA
Aurora kinase A
As of the edition of 20 October 2026, AURKA (aurora kinase A, UniProt O14965) has 18 drugs tested at it and 16 companies on the list, 13 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O14965
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 202
- Disease areas
- Cancer; Blood and lymph; Immune system; Lungs and airways; Skin and connective tissue; Digestive system; Hormones; Urinary and reproductive
- Registered trials of its drugs
- 113
Drugs at this target
| Status | Count |
|---|---|
| Active | 1 |
| Went quiet | 8 |
| Stopped | 9 |
| Total | 18 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Alisertib | Active | Phase 3 | none listed |
| ENMD-981693 | Went quiet | Phase 2 | none listed |
| ENMD-2076 | Went quiet | Phase 2 | none listed |
| Tozasertib | Stopped | Phase 2 | none listed |
| Ilorasertib | Stopped | Phase 2 | none listed |
| Danusertib | Went quiet | Phase 2 | none listed |
| VIC-1911 | Stopped | Phase 1 | none listed |
| AT-9283 | Went quiet | Phase 2 | none listed |
| Cenisertib | Stopped | Phase 1 | none listed |
| MLN-8054 | Stopped | Phase 1 | none listed |
| TAS-119 | Stopped | Phase 1 | none listed |
| CYC-116 | Stopped | Phase 1 | none listed |
12 of 18 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 13 |
| Engaged | 3 |
| Total on the list | 16 |
| Company | Route |
|---|---|
| Merck & Co. | Route A |
| Pfizer | Route A |
| Taiho | Route A |
The other 13 companies at AURKA
In the product16 companies in all; 13 are not named here, and no score is.
See the 16 companies at AURKA, ranked, with the facts behind eachRequest access. Nothing is shown until you do.