Ralfinamide
As of the edition of 20 October 2026, Ralfinamide is a small molecule: went quiet in 2011; acts on CACNA1B, GRIN1 and GRIN2A and 16 more.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Went quiet, 2011
- Kind
- Small molecule
- Registered trials
- 2, 0 stopped early
- Disease areas
- Cancer; Nervous system
US protection
No US approval on record.
With no US approval on record there are no listed US patents or exclusivities.
This is the US only.
Companies that need a new molecule because of this drug
6 company-target rows on route A because of this drug.
Companies on route A for this drug
In the product6 company-target rows are on route A because of Ralfinamide.
See the 6 company-target rows on route A for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Targets
| Gene | Protein | UniProt |
|---|---|---|
| GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O15399 |
| GRIN3B | Glutamate receptor ionotropic, NMDA 3B | O60391 |
| MAOB | Amine oxidase [flavin-containing] B | P27338 |
| SCN1A | Sodium channel protein type 1 subunit alpha | P35498 |
| SCN4A | Sodium channel protein type 4 subunit alpha | P35499 |
| CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Q00975 |
| SCN7A | Sodium channel protein type 7 subunit alpha | Q01118 |
| GRIN1 | Glutamate receptor ionotropic, NMDA 1 | Q05586 |
| GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Q12879 |
| GRIN2B | Glutamate receptor ionotropic, NMDA 2B | Q13224 |
| SCN5A | Sodium channel protein type 5 subunit alpha | Q14524 |
| GRIN2C | Glutamate receptor ionotropic, NMDA 2C | Q14957 |
| SCN9A | Sodium channel protein type 9 subunit alpha | Q15858 |
| GRIN3A | Glutamate receptor ionotropic, NMDA 3A | Q8TCU5 |
| SCN2A | Sodium channel protein type 2 subunit alpha | Q99250 |
| SCN3A | Sodium channel protein type 3 subunit alpha | Q9NY46 |
| SCN11A | Sodium channel protein type 11 subunit alpha | Q9UI33 |
| SCN8A | Sodium channel protein type 8 subunit alpha | Q9UQD0 |
| SCN10A | Sodium channel protein type 10 subunit alpha | Q9Y5Y9 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase 2 | 1 | 1 | 0 | 0 |
| Phase 3 | 1 | 1 | 0 | 0 |
| All trials | 2 |
Who ran its trials
| Company | Role | Years |
|---|---|---|
| Newron Pharmaceuticals | Lead sponsor of trials | 2004 to now |