BRD4
Bromodomain-containing protein 4
As of the edition of 20 October 2026, BRD4 (bromodomain-containing protein 4, UniProt O60885) has 12 drugs tested at it and 15 companies on the list, 9 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O60885
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 639
- Disease areas
- Cancer; Blood and lymph; Heart and blood vessels; Immune system; Lungs and airways; Skin and connective tissue; Hormones; Nutrition and metabolism
- Registered trials of its drugs
- 58
Drugs at this target
| Status | Count |
|---|---|
| Active | 5 |
| Went quiet | 2 |
| Stopped | 5 |
| Total | 12 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Apabetalone | Active | Phase 3 | none listed |
| Pelabresib | Active | Phase 3 | none listed |
| Molibresib | Stopped | Phase 2 | none listed |
| Birabresib | Stopped | Phase 2 | none listed |
| RO-6870810 | Went quiet | Phase 1 | none listed |
| Ezobresib | Active | Phase 2 | none listed |
| AZD-5153 | Went quiet | Phase 3 | none listed |
| INCB054329 | Stopped | Phase 2 | none listed |
| Mivebresib | Stopped | Phase 1 | none listed |
| MT-4561 | Active | Phase 2 | none listed |
| NUV-868 | Stopped | Phase 1 | none listed |
| RNK05047 | Active | Phase 2 | none listed |
12 of 12 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 9 |
| Engaged | 6 |
| Total on the list | 15 |
The other 12 companies at BRD4
In the product15 companies in all; 12 are not named here, and no score is.
See the 15 companies at BRD4, ranked, with the facts behind eachRequest access. Nothing is shown until you do.