Drug

PBF-999

As of the edition of 20 October 2026, PBF-999 is a small molecule: stopped in 2016; acts on ADORA2A and PDE10A.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2016
Kind
Small molecule
Registered trials
3, 1 stopped early
Disease areas
Inherited and neonatal; Mental health; Nervous system; Cancer

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

1 company-target row on route A because of this drug.

Companies on route A for this drug

In the product

1 company-target row is on route A because of PBF-999.

Targets

GeneProteinUniProt
ADORA2AAdenosine receptor A2aP29274
PDE10AcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 13201
All trials3

Who ran its trials

CompanyRoleYears
PalobiofarmaLead sponsor of trials2016 to now