ALOX5
Polyunsaturated fatty acid 5-lipoxygenase
As of the edition of 20 October 2026, ALOX5 (polyunsaturated fatty acid 5-lipoxygenase, UniProt P09917) has 4 drugs tested at it and 6 companies on the list, 3 on route A and 1 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P09917
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 9
- Disease areas
- Lungs and airways; Immune system; Blood and lymph; Cancer; Heart and blood vessels; Chemically induced; Inherited and neonatal; Mental health
- Registered trials of its drugs
- 26
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 1 |
| Went quiet | 1 |
| Stopped | 2 |
| Total | 4 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Zileuton | Marketed | Phase 4 | none listed |
| Setileuton | Stopped | Phase 2 | none listed |
| Atreleuton | Went quiet | Phase 2 | none listed |
| PF-4191834 | Stopped | Phase 2 | none listed |
4 of 4 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 3 |
| Route B | 1 |
| Undetermined | 2 |
| Total on the list | 6 |
| Company | Route |
|---|---|
| Pfizer | Route A |
| Merck & Co. | Route A |
| Chiesi | Route B |
The other 3 companies at ALOX5
In the product6 companies in all; 3 are not named here, and no score is.
See the 6 companies at ALOX5, ranked, with the facts behind eachRequest access. Nothing is shown until you do.