ENPP2
Autotaxin
As of the edition of 20 October 2026, ENPP2 (autotaxin, UniProt Q13822) has 3 drugs tested at it and 3 companies on the list, 1 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q13822
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- Secreted
- Solved structures
- 9
- Disease areas
- Lungs and airways; Skin and connective tissue; Cancer; Digestive system; Hormones
- Registered trials of its drugs
- 15
Drugs at this target
| Status | Count |
|---|---|
| Active | 1 |
| Stopped | 1 |
| Status not established | 1 |
| Total | 3 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Ziritaxestat | Stopped | Phase 3 | none listed |
| BBT-877 | Active | Phase 2 | none listed |
| Cambritaxestat | Status not established | Phase 2 | none listed |
3 of 3 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 1 |
| Engaged | 1 |
| Undetermined | 1 |
| Total on the list | 3 |
| Company | Route |
|---|---|
| Lakefront Biotherapeutics | Route A |
The other 2 companies at ENPP2
In the product3 companies in all; 2 are not named here, and no score is.
See the 3 companies at ENPP2, ranked, with the facts behind eachRequest access. Nothing is shown until you do.